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Design and synthesis of a bismethylsulfanyl-steroid-azetyl butanol derivative from 2-nitroestradiol |
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| Authors: | Figueroa-Valverde Lauro Diaz C Francisco Lopez-Ramos Maria Garcia-Martinez Rolando Rosas-Nexticapa Marcela Mateu-Armand Virginia Garcimarero-Espino E Alejandra Borges-Ballote Yaritza Ortiz-Ake Yazmin |
| Institution: | 1. Laboratory of Pharmacochemistry, Faculty of Biological Chemical Sciences, University Autonomous of Campeche, Campeche, Mexico;2. Escuela de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico;3. Medicos y Odontologos s/n, Universidad Veracruzana, Xalapa, Mexico |
| Abstract: | Several studies for the synthesis of polycyclic derivatives have been reported; however, there is little information on the preparation of steroid-polycyclic derivatives. In this way, the aim of this study was to synthesize a bismethylsulfanyl-steroid-azetyl butanol derivative (compound 10 ) from 2-nitroestrone. The chemical structure was evaluated through both 1H NMR and 13C NMR or spectroscopic analysis. The results showed a good yielding from 10 . It is noteworthy that the reagents used in this investigation are not expensive and do not require special conditions for handling. |
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