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T3P-promoted synthesis of a series of novel 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones |
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| Authors: | Lee J Silverberg Carlos Pacheco Debashish Sahu Peter Scholl Hany F Sobhi Joshua T Bachert Kaitlyn Bandholz Ryan V Bendinsky Heather G Bradley Baylee K Colburn David J Coyle Jonathon R Dahl Megan Felty Ryan F Fox Kyanna M Gonzalez Jasra M Islam Stacy E Koperna Quentin J Moyer Duncan J Noble Melissa E Ramirez Ziwei Yang |
| Institution: | 1. Department of Chemistry, Pennsylvania State University, Schuylkill Haven, Pennsylvania;2. Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania;3. Spectroscopy and Mass Spectrometry Branch, Food and Drug Administration, College Park, Maryland;4. Department of Chemistry, Science and Technology Center, Coppin State University, Baltimore, Maryland |
| Abstract: | A series of 11 novel 3-aryl-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of N-aryl-C-phenyl imines with thiosalicylic acid. This provides simple and ready access to N-aryl compounds in this family, which have been generally difficult to prepare. |
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