Synthesis of novel bis- and poly(benzimidazoles) as well as bis- and poly(benzothiazoles) as anticancer agents |
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| Authors: | Ali M S Hebishy Mohamed S Abdelfattah Abdullah Elmorsy Ahmed H M Elwahy |
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| Institution: | 1. Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt;2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt |
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| Abstract: | A synthesis of bis- and poly(benzimidazoles) as well as bis- and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis- or poly(aldehydes) with o-phenylenediamine or 2-aminothiophenol, respectively, in ethanol at reflux in the presence of NaHSO3. The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF-7), liver cancer cell line (HepG-2), and epithelial colorectal adenocarcinoma cells (CaCO-2). Hexakis(benzothiazole) was found to exhibit the highest activity against HepG-2 and MCF-7 cell lines with IC50 values of 21.16 and 13.25 μM, respectively. |
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