Template-engineered metal macrocyclic complexes: Synthesis and biological activity |
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Authors: | Vikas Sangwan Dharam Pal Singh |
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Affiliation: | Department of Chemistry, National Institute of Technology, Kurukshetra, India |
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Abstract: | Three new azamacrocylic complexes of divalent transition-metal ions were synthesized by taking Co(II), Ni(II), and Cu(II) metal ions as templates. The macrocyclic ligand (12Z,52Z,54E)-11,12,13,14,15,16,51,52,53,54,55,56-dodecahydro-2,4,6,8-tetraaza-1 (2,4),5(4,2)-pyrimidine-3,7(1,2)-dibenzenacyclooctaphane-16,56-dione was derived from o-phenylenediamine (OPD) and 2-thiobarbituric acid (TBA). All the complexes were fully characterized through spectroscopic techniques and elemental analyses. The structures of the macrocyclic complexes were determined by IR, UV–vis, ESI-MS, TGA, molar conductance, magnetic moment, and electron spin resonance data. On the basis of the above studies, the complexes may be formulated as [MLX2], in which L is a macrocyclic ligand and X = CH3COO−. All the macrocyclic complexes were biologically screened to evaluate their antimicrobial efficacy. DNA binding study of two representative complexes was performed by UV–vis titrations. |
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Keywords: | antimicrobial DNA binding macrocyclic complex template method |
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