Antitumor,cytotoxic, and antioxidant evaluation of six heterocyclic compounds containing different heterocycle moieties |
| |
| Authors: | Tasneem Mokhtar Radwan Maher Abdel-Aziz El-Hashash Ashraf Abdel-Hamid Farouk Wasfy Suzan Abdelhalim Abdallah |
| |
| Institution: | 1. Chemistry Department, Faculty of Science, Benha University, Benha, Egypt;2. Chemistry Department, Faculty of Science, Ain-Shams University, Cairo, Egypt;3. Botany and Microbiology Department, Faculty of Science, Benha University, Benha, Egypt |
| |
| Abstract: | Heterocyclic compounds with different heterocycle moieties, namely benzoxazinone, benzimidazole, quinazolinone, and benzofuranone heterocyclic rings, were synthesized, characterized, and evaluated for their anticancer activity against human hepatocellular carcinoma cell line (HepG2) using sulforhodamine B (SRB) and dimethylthiazol-diphenyltetrazolium bromide (MTT) assays. Also, their cytotoxic activities were tested against human epithelioid carcinoma (Hela) cell line in comparison with normal cell, amniotic epithelial (WISH) cell line, as an in vitro toxicity estimation model. The results showed clearly that 2-(2-benzyl-4-oxoquinazolin-3(4H)-yl)acetohydrazide 4 is the most potent antioxidant and anticancer agents. Although, 3-amino-2-benzylquinazolin-4(3H)-one 5 is less potent anticancer agent against Hela but it is more safe against normal cell (WISH). |
| |
| Keywords: | |
|
|
