New azoloazine derivatives as antimicrobial agents: Synthesis under microwave irradiations,structure elucidation,and antimicrobial activity |
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| Authors: | Asmaa F Kassem Eman MH Abbas Nadia T Al-Qurashi Thoraya A Farghaly |
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| Institution: | 1. Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Center, 33 El Bohouth Street (former El Tahrir St.) Dokki, Giza, P.O. Box 12622 Egypt;2. Department of Basic Science, University College in Adam, Umm Al-Qura University, Makkah, Almukkarramah, Saudi Arabia;3. Department of Chemistry, Faculty of Science, Cairo University, Giza, 1263 Egypt |
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| Abstract: | With aiding of microwave radiation, new series of fused-thiazolopyrimidines and fused-triazolopyrimidines each with cycloheptane have been synthesized through the reaction of cycloheptane-thione with α-haloketones or hydrazonoyl chlorides in short-time intervals as well as high yield. Moreover, reaction of 2,7-bis(2-chlorobenzylidene)cycloheptan-1-one with o-aminothiophenol and heterocyclic amines afforded benzob]cycloheptae]1,4]thiazepine derivative and cycloheptapyrimidines fused with different azoles, respectively. The structure for all products was discussed and proved based on the results of spectral data and elemental analysis. Evaluation of the antimicrobial activity of selected products indicated that most of derivatives showed their potent activity exceeds the reference antibiotic in some cases. |
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