Synthesis and antifungal activity of novel 1,2,4-triazole derivatives containing an amide moiety |
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| Authors: | Wen-Neng Wu Yang-Ming Jiang Qiang Fei Hai-Tang Du Mao-Fa Yang |
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| Institution: | 1. Institute of Entomology, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China;2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China;3. Food and Pharmaceutical Engineering Institute, Guiyang University, Guiyang, China |
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| Abstract: | A series of novel 1,2,4-triazol derivatives containing an amide moiety were synthesized and their antifungal activities were evaluated. The results indicated that some of the target compounds possessed good antifungal activities. Among them, compounds 6a , 6g , 6k , and 6m showed excellent antifungal activities against Botrytis cinerea, with an inhibition rate of 91.8%, 90.1%, 93.6%, and 91.2% at a concentration of 50 μg/mL, which were superior to that of Pyrimethanil (82.8%). Meanwhile, compound 6b showed better antifungal activity against Phompsis sp, with an inhibition rate of 92.4%, in comparison with that of Pyrimethanil (85.1%). |
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