Syringaldehyde as a scaffold for the synthesis of some biologically potent heterocycles |
| |
| Authors: | Ahmed S A Youssef Magdy M Hemdan Mohammad E Azab Samir A Emara Galal A Elsayed Rabaa M Kamel |
| |
| Institution: | Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt |
| |
| Abstract: | Syringaldehyde was utilized in synthesis of different heterocyclic systems. Some of the synthesized compounds 2 , 7 , 8 , 10 , 11 , and 13 were tested for antioxidant activity where they showed ability to inhibit oxidation in kidney and rat brain homogenates using 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Also, the activity against cancer was examined using the standard MTT method for two human tumor cell lines namely; mammary gland breast cancer MCF-7 and hepatocellular carcinoma HepG2. The highest activity as antioxidant and antitumor agents was exhibited by compounds 8 and 11 . However, moderate activities were shown by compounds 10 and 13 . While, compounds 2 , 7 showed weak activities. |
| |
| Keywords: | |
|
|
