|
|||||
|
|
Thionyl chloride-mediated synthesis of 2-azaindolizine sulfur-bridged dimers by C?H bond direct chalcogenation of imidazo[1,5-a]pyridines |
|
| Authors: | Mahesh R Kulkarni Nitin P Lad Shashikant M Patil Nitin D Gaikwad |
| Institution: | 1. Department of Chemistry, Organic Chemistry Research Centre, K.R.T. Arts, B.H. Commerce and A.M. Science College, Nashik, India
Department of Medicinal Chemistry, Piramal Enterprises Ltd., Mumbai, India;2. Department of Medicinal Chemistry, Piramal Enterprises Ltd., Mumbai, India;3. Department of Chemistry, Organic Chemistry Research Centre, K.R.T. Arts, B.H. Commerce and A.M. Science College, Nashik, India |
| Abstract: | Thionyl chloride-mediated chalcogenation of imidazo1,5-a]pyridine serves as a new protocol for the synthesis of rare bisimidazopyridyl sulfides. This method provides the new route to synthesis of 2-azaindolizine sulfur-bridged dimers called chalcogenide under metal-free, elemental sulfur-free conditions without the use of polar solvents in regio-selective manner, at room temperature with the simple operational procedure. |
| Keywords: | bis-imidazopyridyl sulfides C?H activation C?H chalcogenations chlorination thionyl chloride |