A simple and efficient route to 2-arylimidazo[1,2-a]pyridines and zolimidine using automated grindstone chemistry |
| |
| Authors: | Dharmendra Das Zigmee T. Bhutia Padmini C. Panjikar Amrita Chatterjee Mainak Banerjee |
| |
| Affiliation: | 1. Department of Chemistry, BITS Pilani, K. K. Birla Goa Campus, Zuarinagar, Goa, India;2. Department of Chemistry, BITS Pilani, K. K. Birla Goa Campus, Zuarinagar, Goa, India Pravatibai Chowgule College of Arts and Science (Autonomus), Margao, Goa, India |
| |
| Abstract: | A green and efficient mechanochemical method for the synthesis of a series of 2-arylimidazo[1,2-a]pyridines was developed using an electrical grinder. I2 catalyzed mechanochemical grinding facilitates the cyclocondensation reaction between various aryl methyl ketones and 2-aminopyridines to afford 2-arylimidazo[1,2-a]pyridines in good yields at ambient temperature. The method was successfully used for the gram-scale synthesis of a marketed drug, zolimidine. The noticeable advantages of this environmentally sustainable protocol include mild conditions, simple instrumentation, inexpensive catalyst, atom economy, short reaction time etc. |
| |
| Keywords: | |
|
|
