Iodine-catalyzed ultrasound-assisted construction of pyridines and their glutamine synthetase molecular docking |
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| Authors: | Ramakanth Pagadala Venkatesan Kasi Shyam Perugu |
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| Affiliation: | 1. Chemistry Division, H&S Department, CVR College of Engineering, Hyderabad, India;2. Department of Biotechnology, National Institute of Technology, Warangal, India |
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| Abstract: | Iodine-promoted facile protocol is designed for the production of pyridines at room temperature under ultrasound irradiation. Eleven pyridine derivatives in excellent yields (91–97%) are synthesized with 2 hr reaction time. Additional advantage of the proposed ultrasound-assisted eco-friendly, cost-effective protocol is easy separation of product, and our in silico studies show good binding affinity toward binding and made strong hydrogen interactions. |
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| Keywords: | C?C and C?N bond formation docking study iodine multicomponent pyridines ultrasound |
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