Convenient synthesis of functionalized thieno[2,3-d]pyrimidine-4-ones and thieno[2,3-b]pyridine-4-ones bearing a pyridine moiety with anticipated antioxidant activity |
| |
Authors: | Ahmed El-Mekabaty Abd El-Aziz S. Fouda Ibrahim E. I. Shaaban |
| |
Affiliation: | Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt |
| |
Abstract: | In the present study, ethyl 2-amino-4-methyl-5-(pyridin-2-ylcarbamoyl)thiophene-3-carboxylate (2) has been achieved using the Gewald's methodology and served as a synthon for the synthesis of various derivatives of thieno[2,3-d]pyrimidine-4-one and thieno[2,3-b]pyridine-4-one bearing a pyridine moiety via its reactions with the convenient chemical reagents. The antioxidant performance has been tested using the ABTS method and the results disclosed that thienopyrimidinone 5 and thienopyridinones 18 and 19 have the most potent antioxidant efficiency with inhibition percentage at 84.41%, 80.95%, and 76.93%, respectively, compared with ascorbic acid as a reference drug. |
| |
Keywords: | |
|
|