ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity |
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| Authors: | Naghmeh Faal Hamedani Maryam Ghazvini Fatemeh Sheikholeslami-Farahani Mohammad Taghi Bagherian-Jamnani |
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| Institution: | 1. Department of Chemistry, Faculty of Valiasr, Tehran Branch, Technical and Vocational University (TVU), Tehran, Iran;2. Department of Chemistry, Payame Noor university, Tehran, Iran;3. Department of Chemistry, Firoozkooh Branch, Islamic Azad University, Firoozkooh, Iran;4. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran |
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| Abstract: | In this work, thiophene derivatives were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides, activated acetylenic compounds, isothiocyanates, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent-free conditions. This procedure for the synthesis of thiophene derivatives is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, 5b , 5d , 5e , and 5f . As outcome, the compound 5d exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2-tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. The obtained results of disk diffusion test showed that compounds 5b , 5d , 5e , and 5f prevented bacterial growth. |
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