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An efficient synthesis of 9-anthrone lactone derivatives via the Knoevenagel condensation and intramolecular cyclization |
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| Authors: | Weiqiang Tan Jifang Zheng Jing Guan Xiuzhi Zhan Liming Gao Lili Lyu Bin Shan Qipeng Yang Mingliang Ma Yan Xia |
| Affiliation: | 1. School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, China;2. Research Institute of Functional Materials, School of Civil Engineering, Qingdao University of Technology, Qingdao, China;3. School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, China Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China |
| Abstract: | One-step synthesis of 9-anthrone lactone derivatives from 1-acetyloxyanthraquinone with a variety of dicarbonyl substrates in the presence of K2CO3 by Knovenagel condensation and intramolecular cyclization is developed. Possible reaction mechanisms have been investigated using the density functional theory (DFT), which has been widely used in the study of reaction mechanism. The strategy could be useful for the synthesis of the core structure of marine natural product aspergiolide. |
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