Synthesis and antifungal activities of 3,5-diphenyl-7-amino-[1,3]-thiazolo[3,2-a]pyrimidine-6-nitrile derivatives |
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| Authors: | Susanta Kumar Borthakur Pabitra Kumar Kalita Sukanya Borthakur |
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| Affiliation: | 1. Department of Chemistry, Arya Vidyapeeth College, Guwahati, Assam, India;2. Department of Chemistry, Sibsagar College, Sivasagar, Assam, India;3. Materials Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, India Academy of Scientific and Innovative Research, New Delhi, India |
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| Abstract: | A series of novel 3,7-diphenyl-7-amino[1,3]-thiazolo[3,2-a]pyrimidine-6-nitrile derivatives 3 were synthesized by refluxing 2-amino-4-phenyl-1,3-thiazole 1 and arylidinemalononitrile 2 in propanol using NaOH as catalyst. Various synthesized products were characterized by 1H NMR, mass spectrometry (MS), infrared (IR), and elemental analysis. Antifungal activities of the synthesized compounds were done by testing against Rhizoctonia solani and Drechslera orazae, two fungal pathogens causing diseases on rice crops. |
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