The first solid-phase synthesis of bis(oxazolinyl)pyridine ligands |
| |
Authors: | Weissberg Avi Halak Baruch Portnoy Moshe |
| |
Institution: | School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel. |
| |
Abstract: | Chiral Pybox (pyridine-2,6-bis(oxazoline)) ligands can be cleanly and efficiently prepared on polystyrene support via a five-step solid-phase synthetic sequence. Cu(I)-complexed polymer-bound Pybox was used as a catalyst in the first heterogeneously catalyzed asymmetric addition of alkynes to imines. Best enantioselectivity was observed with (t)Bu-substituted oxazolines. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|