| Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity |
| |
| 作者姓名： | Yao Liu~ |
| |
| 作者单位： | a School of Pharmacy, Jilin University, Changchun 130021, China;b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;c Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;d Lindsley F. Kimball Research Institute, The New York Blood Center, New York, NY 10021, USA |
| |
| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金，SL and the Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences |
| |
| 摘 要： | A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ^1H-NMR. These compounds exhibited potent anti-HIV-1 activities.
|
| 关 键 词： | HIV-1 抑制剂 苯并二氮 合成方法 抗艾滋病病毒活性 |
Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity |
| |
| Yao Liu.Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity[J].Chinese Chemical Letters,2008,19(4):428-430. |
| |
| Authors: | Yao Liu Jing Su Jun Hai Xiao Shi Bo Jiang Hong Lu Wu Zhong Li Li Wang Xiao Hong Yang Song Li |
| |
| Institution: | a School of Pharmacy, Jilin University, Changchun 130021, China;b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;c Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;d Lindsley F. Kimball Research Institute, The New York Blood Center, New York, NY 10021, USA |
| |
| Abstract: | A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and 1H-NMR.These compounds exhibited potent anti-HIV-1 activities. |
| |
| Keywords: | HIV-1 entry inhibitors Benzoeycloheptene derivatives Synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
