A practical synthesis of D-erythro-sphingosine using a cross-metathesis approach |
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Authors: | Torssell Staffan Somfai Peter |
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Institution: | Organic Chemistry, KTH Chemistry, Royal Institute of Technology, S-100 44 Stockholm, Sweden. |
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Abstract: | Starting from a vinylepoxide, a short and practical synthesis of D-erythro-sphingosine is described. The key transformations are a regioselective opening of the vinylepoxide and an E-selective cross-metathesis, affording the target molecule 5 in steps and 51% overall yield. |
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