Diverse trifluoromethyl heterocycles from a single precursor |
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Authors: | Honey Mark A Pasceri Raffaele Lewis William Moody Christopher J |
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Institution: | School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK. |
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Abstract: | Ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate is a highly versatile intermediate for the synthesis of a wide range of trifluoromethyl heterocycles. With the use of rhodium(II) or copper(II) catalyzed carbene X-H insertion reactions as key steps, a diverse set of trifluoromethyl-oxazoles, -thiazoles, -imidazoles, -1,2,4-triazines, and -pyridines are available from the diazoketoester, either directly in a single step or with just one additional step. |
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