| Abstract: | Methods were developed for the synthesis of 2-ethoxy-1,4-butanediol and 2-ethoxy-1,4-pentanediol. The latter was a mixture of diastereomers. These diols were used to synthesize 5-ethoxy-1,3-dioxepan and 2,2,4-trimethyl-6-ethoxy-1,3-dioxepan. Gas-liquid chromatography was used to demonstrate that 2,2,4-trimethyl-6-ethoxy-1,3-dioxepan is a mixture of cis and trans isomers; the ratio of these isomers is similar to the ratio of diastereomers in the starting 2-ethoxy-1,4-pentanediol. The configurations of the indicated isomers were evaluated by conformational analysis.See [1] for communication XIII.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 3–6, January, 1972. |
