Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix |
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| Authors: | Cline Daniel J Holt Shannon L Singleton Scott F |
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| Institution: | School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA. |
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| Abstract: | Bacterial RecA promotes the development and transmission of antibiotic resistance genes by self-assembling into an ATP-hydrolyzing filamentous homopolymer on single-stranded DNA. We report the design of a 29mer peptide based on the RecA N-terminal domain involved in intermonomer contact that inhibits RecA filament assembly with an IC50 of 3 microM. |
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