Boron-mediated aldol reactions of ethyl α-(<i>N</i>,<i>N</i>)-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Boron-mediated aldol reactions of ethyl α-(N,N)-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity

Authors:	Ian Paterson Angela C Mackay

Abstract:	The boron-mediated aldol reactions of a range of chiral α-(N,N)-dibenzylamino ketones with aldehydes can be controlled to provide stereodefined adducts. Complementary induction can be achieved with ^cHex₂BCl/Me₂NEt leading to preferential formation of the 1,2-anti-2,4-syn adducts, while Bu₂BOTf/ⁱPr₂NEt provides 1,2-syn-2,4-anti adducts.

Keywords:	boron aldol amino acids amino ketones stereoinduction libraries
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