Absorption and excretion of suprofen in both sexes of rats, guinea pigs, and rabbits |
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Authors: | Y Mori F Yokoya Y Sakai K Toyoshi T Furuta S Baba |
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Abstract: | DL-2-(4-2-Thienylcarbonyl)phenyl)propionic acid (suprofen) was rapidly absorbed in both sexes of rats, guinea pigs, and rabbits after oral administration. Blood levels after a single dose of 2 mg/kg 3H-suprofen in all the animals reached maxima within 15 min, and elimination of the 3H from blood was rapid; the radioactivity was mostly excreted in the urine and feces within 24 h after dosing. |
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