Electrochemiluminescence immunosensor for the determination of ag alpha fetoprotein based on energy scavenging of quantum dots |
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| Authors: | Zhiyong Guo Tingting HaoSui Wang Ning GanXing Li Danyi Wei |
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| Institution: | Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, PR China |
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| Abstract: | An electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of alpha fetoprotein (AFP) was fabricated using graphene-CdS quantum dots-alginate (G-CdS QDs-AL) as the immobilizing support and CdSe/ZnS QDs as the label. CdSe/ZnS QDs could effectively scavenge the ECL of G-CdS QDs-AL composite, and the quenched ECL intensity depended linearly on the logarithm for AFP concentration in the range from 0.05 to 500 fg/mL. The detection limit was 20 ag/mL. The proposed ECL immunoassay protocol for AFP detection is stable, specific, highly sensitive and promising for clinical application. |
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| Keywords: | Electrochemiluminescence Immunosensor Alpha fetoprotein Graphene-CdS quantum dots-alginate composites Energy scavenging |
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