The copper-catalyzed N-arylation of indoles |
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| Authors: | Antilla Jon C Klapars Artis Buchwald Stephen L |
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| Institution: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
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| Abstract: | A general method for the N-arylation of indoles using catalysts derived from CuI and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles. |
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