Total synthesis of zincophorin methyl ester |
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Authors: | Defosseux Magali Blanchard Nicolas Meyer Christophe Cossy Janine |
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Affiliation: | Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. |
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Abstract: | [reaction: see text]. A convergent total synthesis of the methyl ester of zincophorin, an ionophore antibiotic, has been realized relying on a diastereoselective titanium-mediated aldol coupling between the C1-C12 and C13-C25 subunits. The latter fragment was prepared by using a Carroll-Claisen rearrangement. |
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