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Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation |
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| Authors: | Pastine Stefan J Sames Dalibor |
| Institution: | Department of Chemistry, Columbia University, New York, New York 10027, USA. |
| Abstract: | reaction: see text]. A concise total synthesis of (+/-)-deguelin was achieved with a longest linear sequence of six steps in 68% yield. A key step was the platinum-catalyzed 6-endo hydroarylation of an alkynone intermediate. |
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