Total synthesis and conformational analysis of the antifungal agent (-)-PF1163B |
| |
| Authors: | Bouazza Fodil Renoux Brigitte Bachmann Christian Gesson Jean-Pierre |
| |
| Institution: | UMR 6514, University of Poitiers and CNRS, 40 avenue du recteur Pineau, 86022 Poitiers, France. |
| |
| Abstract: | reaction: see text]. (-)-PF1163B, a new macrocyclic antifungal antibiotic isolated from Streptomyces sp., has been prepared in eight steps from (S)-citronellene. The key step is a ring-closing metathesis reaction of an ester and amide derivative obtained from a substituted N-methyl-l-tyrosine. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
