| 载银二氧化钛纳米管表面pH敏感膜构建及其抑菌特性 |
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| 引用本文： | 郭志君,胡盼,王立军,周斌,李玉宝,张利. 载银二氧化钛纳米管表面pH敏感膜构建及其抑菌特性[J]. 无机化学学报, 2014, 30(6): 1299-1304 |
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| 作者姓名： | 郭志君 胡盼 王立军 周斌 李玉宝 张利 |
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| 作者单位： | 四川大学分析测试中心, 纳米生物材料研究中心, 成都 610064;四川大学分析测试中心, 纳米生物材料研究中心, 成都 610064;四川大学分析测试中心, 纳米生物材料研究中心, 成都 610064;四川大学材料科学与工程学院, 成都 610064;四川大学分析测试中心, 纳米生物材料研究中心, 成都 610064;四川大学分析测试中心, 纳米生物材料研究中心, 成都 610064 |
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| 基金项目： | 国家重大科学研究计划(2012CB933902)资助项目。 |
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| 摘 要： | 采用表面涂覆硅烷偶联剂KH550、两步光接枝、阳极氧化等方法,在钛表面成功制备出一种pH型敏感膜覆盖的载银二氧化钛(TiO2)纳米管阵列。利用扫描电镜(SEM)、透射电镜(TEM)、能谱分析(EDS)、原子吸收光谱(AAS)对该pH敏感膜覆盖的载银TiO2纳米管阵列理化性能进行了表征,采用抑菌环实验定性考察了样品的抗菌特性,并计算其抑菌率。结果表明,含银离子溶液在毛细管力作用下大量进入TiO2纳米管中,并在pH型敏感膜的调控下,使银离子在不同pH环境下具备不同的释放行为,从而达到良好的控释效果;载银TiO2纳米管的抑菌率与银离子负载量成正比,且抗菌性能持久。
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| 关 键 词： | 钛种植体 二氧化钛纳米管 银离子 pH敏感膜 智能控释 抗菌性能 |
| 收稿时间： | 2013-10-10 |
| 修稿时间： | 2013-11-29 |
Fabrication of pH-Sensitive Membrane on Ag-Loaded Titania Nanotube and Its Antibacterial Properties |
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| GUO Zhi-Jun,Hu Pan,WANG Li-Jun,ZHOU Bin,Li Yu-Bao and ZHANG Li. Fabrication of pH-Sensitive Membrane on Ag-Loaded Titania Nanotube and Its Antibacterial Properties[J]. Chinese Journal of Inorganic Chemistry, 2014, 30(6): 1299-1304 |
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| Authors: | GUO Zhi-Jun Hu Pan WANG Li-Jun ZHOU Bin Li Yu-Bao ZHANG Li |
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| Affiliation: | Analytical & Testing Center, Research Center for Nano-biomaterials, Sichuan University, Chengdu 610064, China;Analytical & Testing Center, Research Center for Nano-biomaterials, Sichuan University, Chengdu 610064, China;Analytical & Testing Center, Research Center for Nano-biomaterials, Sichuan University, Chengdu 610064, China;College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China;Analytical & Testing Center, Research Center for Nano-biomaterials, Sichuan University, Chengdu 610064, China;Analytical & Testing Center, Research Center for Nano-biomaterials, Sichuan University, Chengdu 610064, China |
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| Abstract: | Ag-loaded TiO2 nanotube covered by a pH-sensitive membrane were prepared by coating a silane coupling agent KH550 accompanied with a two-step photo-grafting and anodization, and its physicochemical properties were characterized by means of SEM, TEM, EDSand AES. Also, the antibacterial activities of these samples were accessed by inhibition zone and inhibition rate. The results suggest that, the solution containing Ag ions enters into the interior of TiO2 nanotubes under the interactions of capillary force, and the release behavior of Ag ions is regulated and controlled by the pH-sensitive polymer membrane at different pHenvironment. Also, it is found that the antibacterial ratio of Ag-carried nanotubes is proportional to the carrying content of Ag ions. |
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| Keywords: | titanium implant TiO2 nanotubes Ag ions pH-sensitive membrane intelligent controlled release antibacterial activity |
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