| 对酞内酰胺苯甲酰氯柱前衍生反应HPLC法检测痕量芳香胺 |
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| 引用本文： | 郭玉凤,傅承光.对酞内酰胺苯甲酰氯柱前衍生反应HPLC法检测痕量芳香胺[J].分析测试学报,1997,16(2):61-63. |
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| 作者姓名： | 郭玉凤 傅承光 |
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| 作者单位： | 承德医学院化学教研室，河北大学理化分析中心 |
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| 摘 要： | 建立了一种快速、灵敏检测痕量芳香胺的新方法。对苯胺、邻甲苯胺和间甲苯胺与对酞内酰胺苯甲酰氯（简称ＰＩＢ－Ｃｌ）的衍生反应条件、衍生物色谱分离及定量检测条件等进行了研究。衍生试剂在有机溶剂中与３种芳香胺反应迅速，衍生物用乙腈＋水（４８＋５２）作流动相，在反相色谱系统中得到了良好的分离。３种芳香胺的检出限分别为：苯胺１．５ｐｍｏｌ，邻甲苯胺和间甲苯胺均为２．０ｐｍｏｌ。
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| 关 键 词： | 芳香胺，对酞内酰胺苯甲酰氯，高效液相色谱 |
HPLC Determination of Trace Aromatic Amines by Pre column Derivatization with 4 (2 Phthalimidyl)Benzoyl Chloride |
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| Guo Yufeng,Li Jingyin.HPLC Determination of Trace Aromatic Amines by Pre column Derivatization with 4 (2 Phthalimidyl)Benzoyl Chloride[J].Journal of Instrumental Analysis,1997,16(2):61-63. |
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| Authors: | Guo Yufeng Li Jingyin |
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| Abstract: | The paper covers a simple,rapid and sensitive method for determination of trace aniline and toluidines by HPLC. The optimum experimental conditions have been established. Firstly, the samples were treated with 4 (2 phthalimidyl)benzoyl chloride, then produce the corresponding amides which can be separated on ODS column with acetonitrile/water (48/52,V/V)as mobile phase. The eluates were quantitatively detected by UV detector at 295 nm. The detection limits were 1.5 pmol for aniline and 2.0 pmol for both o and m toluidine. |
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| Keywords: | Aromatic amines 4 (2 Phthalimidyl) benzoyl chloride HPLC |
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