| 具有生物活性钼钨仿生配合物与ATP作用的NMR研究 |
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| 引用本文： | 毕研刚,李志强,喻冲,史旭东,钟利娟,闵涛,鲁晓明. 具有生物活性钼钨仿生配合物与ATP作用的NMR研究[J]. 波谱学杂志, 2010, 27(4): 562-571. DOI: 10.3969/j.issn.1000-4556.2010.04.007 |
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| 作者姓名： | 毕研刚 李志强 喻冲 史旭东 钟利娟 闵涛 鲁晓明 |
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| 作者单位： | 首都师范大学,化学系,北京,100048;首都师范大学,化学系,北京,100048;中国科学院,武汉物理与数学研究所,湖北,武汉,430071 |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | 在常温下合成了以邻苯二酚为配体,分别以乙二胺、1,2-丙二胺、1,3-丙二胺为抗衡离子的7种手性钼钨八面体配合物(NH2CH2CH2NH3)3[Mo(V)O2(OC6H4O)2](1),(NH2CH2CH2NH3)2[W(VI)O2(OC6H4O)2](2),(NH2CH2CH2NH3)2.5[Mo(V)0.5W(VI)0.5O2(O2C6H4)]2](3),(NH3CH2CHNH2CH3)3[Mo(V)O2(OC6H4O)2](4),(NH3CH2CHNH2CH3)2[W(VI)O2(OC6H4O)2](5),(NH3CH2CHNH2CH3)2.5[Mo(V)0.5W(VI)0.5O2(OC6H4O)2](6),(NH3CH2CH2CH3NH2)2.5[Mo(V)0.5W(VI)0.5O2(OC6H4O)2](7),并在生理条件下对其与ATP的相互作用进行了液体NMR研究,发现标题配合物的中心金属离子在纯D2O溶剂中大多数以+5价形式存在,W(VI)被还原为W(V),但与ATP混合后又转化为+6价,配合物原有的顺磁性特征完全消失.研究还发现ATP可以促进中心离子与原配体发生解离.
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| 关 键 词： | 核磁共振(NMR) ATP 邻苯二酚 钼钨配合物 |
| 收稿时间： | 2010-04-29 |
An NMR Study on the Interaction between ATP and Biologically Active Molybdenum and Tungsten Bionic Complexes |
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| BI Yan-gang,LI Zhi-qiang,YU Chong,SHI Xu-dong,ZHONG Li-juan,MIN Tao,LU Xiao-ming. An NMR Study on the Interaction between ATP and Biologically Active Molybdenum and Tungsten Bionic Complexes[J]. Chinese Journal of Magnetic Resonance, 2010, 27(4): 562-571. DOI: 10.3969/j.issn.1000-4556.2010.04.007 |
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| Authors: | BI Yan-gang LI Zhi-qiang YU Chong SHI Xu-dong ZHONG Li-juan MIN Tao LU Xiao-ming |
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| Affiliation: | 1. Department of Chemistry, Capital Normal University, Beijing 100048, China;;2. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China |
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| Abstract: | Seven molybdenum and tungsten octahedral complexes, with benzene-1,2-diol as a ligand and ethylenediamine 1, 2-diaminopropane and 1, 3-diaminopropane as counterions, respectively, were synthesized under normal temperature. The interactions between adenosine triphosphate (ATP) and these compounds: (NH2CH2CH2NH3)3[Mo(V)O2(OC6H4O)2] (1)，(NH2CH2CH2NH3)2[W(VI)O2(OC6H4O)2] (2)，(NH2CH2CH2NH3)2.5[Mo(V)0.5W(VI)0.5O2(O2C6H4)]2] (3)，(NH3CH2CHNH2CH3)3[Mo(V)O2(OC6H4O)2] (4)，(NH3 CH2CHNH2CH3)2[W(VI)O2(OC6H4O)2] (5)，(NH3CH2CHNH2CH3)2.5[Mo(V)0.5W(VI)0.5O2(OC6H4O)2] (6)，(NH3CH2CH2CH3NH2)2.5[Mo(V)0.5W(VI)0.5O2 (OC6H4 O)2] (7) were studied by LC-NMR. The results showed that the valence of the center ions were +5 when the complexes were dissolved in D2O and the reduction of W(VI) to W(V) occurs . W(V) could be oxidized again when ATP solution was mixed with the original solution and hydrolysis of benzene-1,2-diol ligand took place. |
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| Keywords: | NMR ATP benzene-1 2-diol molybdenum and tungsten complexes |
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