Solid-supported reagents and catalysts for the preparation of large ring compounds |
| |
Authors: | Elisabeth Gonthier Rolf Breinbauer |
| |
Affiliation: | (1) Fachbereich Chemie, University Dortmund, Dortmund, Germany;(2) Max-Planck-Institute for Molecular Physiology, Dortmund, Germany |
| |
Abstract: | Parallel combinatorial synthesis in solution using immobilized reagents, catalysts, and scavengers has emerged as a powerful technique for the preparation of diverse libraries of compounds. This technique has only recently been applied to the synthesis of large-ring compounds. In this comprehensive review several strategies are presented and discussed, including Pd-catalyzed allylic alkylation, Stille-coupling, macrolactonization and macrolactamization using solid supported reagents and catalysts. In several cases site isolation has allowed operation of these macrocyclization reactions in concentrated solution (pseudo-dilution effect). |
| |
Keywords: | catalyst combinatorial chemistry esterification large-rings macrolactonization macrocyclization palladium solid-phase solid-supported reagents transition metal |
本文献已被 PubMed SpringerLink 等数据库收录! |
|