Bromination of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(2′-difluoromethoxyphenyl)-1,4-dihydropyridine (foridone)

The action of mild brominating agents (pyridinium bromide-perbromide, dioxan dibromide N-bromosuccinimide, and N-bromoacetamide) on 2,6-dimethyl-3,5-dimethoxy-carbonyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine (Foridone) has been studied. Depending on reaction conditions, furo-, difuro-, and dibromomethyl-1,4-dihydropyridines are obtained together with certain oxidized forms.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 948–952, July, 1989.