Synthesis and biological application of pyranopyrimidine derivatives catalyzed by efficient nanoparticles and their nucleoside analogues

Abstract

Nanoparticles supply an environmentally friendly procedure for the synthesis of pyrano2,3-d]pyrimidines by the one-pot three-component condensation reaction of thiobarbituric acid and malononitrile with pyrrol-2-carboxaldehyde. The catalyst could be easily recovered using an external magnet and reused for six cycles with almost consistent activity. A facile synthesis of a new series of cyclic and acyclic nucleosides of pyrano2,3-d]pyrimidines derivatives was performed. The synthesis of poly heterocyclic compounds starting from pyrano2,3-d]pyrimidines derivatives was achieved. Structures of the newly synthesized compounds were confirmed on the bases of elemental analyses and spectral data (IR, ¹H NMR, ¹³C NMR, and mass spectra). Compound 6 exhibited the most potent biological activity.