Convenient catalytic, enantioselective conjugate reduction of nitroalkenes using CuF2 |
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Authors: | Czekelius Constantin Carreira Erick M |
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Affiliation: | Laboratorium für Organische Chemie, ETH Zürich, ETH H?nggerberg, HCI, H335, CH-8093 Zürich, Switzerland. |
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Abstract: | We document the use of a new catalyst system for the enantioselective conjugate reduction of nitroalkenes utilizing commercially available CuF(2) and the bis-phosphine JOSIPHOS as a ligand. This new protocol not only facilitates ready access to a variety of optically active nitroalkanes, but the results provide also new insight into copper-catalyzed reactions. [reaction: see text] |
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