| First Total Synthesis of an Analogue of (±)-Hypargenin B |
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| 引用本文： | An Pai LI,Hui WANG,Cheng Lu ZHANG,Tong Xing WU,Xin Fu PAN* Department of Chemistry,National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000. First Total Synthesis of an Analogue of (±)-Hypargenin B[J]. 中国化学快报, 2002, 13(2) |
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| 作者姓名： | An Pai LI Hui WANG Cheng Lu ZHANG Tong Xing WU Xin Fu PAN* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 |
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| 作者单位： | An Pai LI，Hui WANG，Cheng Lu ZHANG，Tong Xing WU，Xin Fu PAN* Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 |
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| 基金项目： | We are grateful to the National Natural Science Foundation of China (No. 29372050) for financial support. |
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| 摘 要： | Hypargenin B, a diterpene with the abietane skeleton, was isolated by Ayhan from the root of an endemic species salvia hypargenia and showed antibacterial activity1. In this diterpene, the junction of A/B ring is trans. In order to provide for studying further the relationship between the structure and bioactivities, we develop a novel route whereby the hypargenin B methyl ether 22 could be obtained in good yield. To our knowledge no total synthetic work has been reported on the title com…
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First Total Synthesis of an Analogue of (±)-Hypargenin B |
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| An Pai LI,Hui WANG,Cheng Lu ZHANG,Tong Xing WU,Xin Fu PAN. First Total Synthesis of an Analogue of (±)-Hypargenin B[J]. Chinese Chemical Letters, 2002, 13(2) |
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| Authors: | An Pai LI Hui WANG Cheng Lu ZHANG Tong Xing WU Xin Fu PAN |
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| Abstract: | First total synthesis of (±)-hypargenin B methyl ether 2 was accomplished via a strategy of AC→ABC, in which CrO3/H2O/NaOAc/HOAc system was utilized for introducing 7-keto group in order to avoid dehydration of benzyl tertiary alcohol. |
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| Keywords: | Hypargenin B diterpene intramolecular steroselective. |
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