Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization |
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| Authors: | Holappa Jukka Nevalainen Tapio Safin Rustam Soininen Pasi Asplund Tomas Luttikhedde Tiina Másson Már Järvinen Tomi |
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| Institution: | Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. Jukka.Holappa@uku.fi |
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| Abstract: | Novel synthesis methods for the preparation of quaternary piperazine derivatives of chitosan were developed. Quaternary ammonium moiety can be selectively inserted into either one or both of the piperazine nitrogens, yielding structurally uniform chitosan derivative structures. Water-soluble end products were thoroughly characterized with FT-IR, 1H NMR, 13C NMR and 2D 1H-13C HSQC NMR. The molecular weights of the end products were determined by GPC with triple detection. |
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| Keywords: | chitosan piperazine quaternary synthesis water‐soluble polymers |
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