New approach based on solid-phase extraction for the assessment of organic compound pollutions in so-called pharmaceutically pure water |
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Authors: | Marta Staniszewska Lidia Wolska Jacek Namie?nik |
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Institution: | (1) Department of Maritime Hydrotechnics, Maritime Institute in Gdańsk, Długi Targ 41/42, 80–830 Gdańsk, Poland;(2) Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, Narutowicza 11/12 Str., 80–952 Gdańsk, Poland |
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Abstract: | The application of a new kind of technique involving solid-phase extraction coupled with thermal desorption (SPE-TD) to the
qualitative analysis of water used in pharmaceutical products was evaluated. Comparative analyses performed by the purge and
trap (PT) technique were also conducted. The application of this SPE-TD technique resulted in the isolation of a large number
of compounds from the water sample. The SPE-TD technique is applied to less volatile compounds, whereas the PT technique is
used for more volatile and nonpolar ones. These two techniques should be applied in order to achieve complete identification
and quantitative determination. Additionally, an attempt to identify organic compounds in pharmaceutical products was also
conducted. The compounds present in such products include aldehydes, ketones, hydrocarbons, alcohols, esters. The influence
of storage on the quality of water was also investigated. For samples characterized by a longer storage time, qualitatively
richer chromatograms were obtained, which confirmed that components were released from the packaging (especially polyethylene)
which entered the stored product. |
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Keywords: | Solid-phase extraction Trace organic compounds Pharmaceutical purpose for water |
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