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Preparation and regiochemical assignments of new pyrazolo[3,4-c] [2,1]benzodiazepines
Authors:Esther Arranz  Juan A Díaz  Esther Morante  Carmen Prez  Salvador Vega
Institution:Esther Arranz,Juan A. Díaz,Esther Morante,Carmen Pérez,Salvador Vega
Abstract:The preparation of new pyrazolo3,4-c]2,1]benzothiazepines substituted at the nitrogen atoms of the pyrazole moiety is described. It was carried out by reaction of the 4,9-dihydro-9-methyl-4,10,10-trioxo-1(2)H-pyrazolo3,4-c]2,1]benzothiazepine ( 1 ) with several alkylating agents under both classical and phase-transfer catalysis (PTC) conditions. Assignments of the N-alkyl regioisomers obtained were performed by study of their 1H nmr spectra and NOE experiments.
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