2,6-Diarylhexahydro-4-pyridazinols by acid-catalyzed cyclization of benzaldehyde aryl-2-(2-propenyl)hydrazones |
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| Authors: | Rajagopal Bakthavatchalam Engelbert Ciganek Joseph C. Calabrese |
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| Abstract: | Treatment of benzaldehyde l-(2-propenyl)-4-methylsulfonylphenylhydrazone ( 1f ) with 45% sulfuric acid gave 2-(4-methylsulfonylphenyl)-6-phenylhexahydro-4-pyridazinol ( 2f ) in 35% yield rather than the expected 1-(4-methylsulfonylphenyl)-1-(2-propenyl)hydrazine. The halogen-substituted hydrazones 1c-1e and benzaldehyde 1-(2-methyl-2-propenyl)phenylhydrazone ( 1b ) gave similar results. |
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