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Synthesis of azolylalkylquinolines with cytotoxic activity |
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| Authors: | Mark D. Abel Hiep T. Luu Ronald G. Micetich Dai Q. Nguyen A. Bernadette Oreski Mark L. Tempest Mohsen Daneshtalab |
| Abstract: | The syntheses of various azolylalkylquinoline derivatives in which the nature of the linkage between the quinoline and azolylalkyl moieties of the molecule were altered are described. The compounds were tested for cytotoxic activity towards cancer cells and compound 27 was found to exhibit moderate in vivo activity in a murine sarcoma model. |
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