Novel hexahydrofuro[3,4-b]-2(1H)-pyridones from 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones |
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| Authors: | Alhmed Morales Estael Ochoa Margarita Surez Yamila Verdecia Leandro Gonzlez Nazario Martín Margarita Quinteiro Carlos Seoane Jos L Soto |
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| Institution: | Alhmed Morales,Estael Ochoa,Margarita Suárez,Yamila Verdecia,Leandro González,Nazario Martín,Margarita Quinteiro,Carlos Seoane,José L. Soto |
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| Abstract: | The title compounds 6 have been prepared in a one-step procedure from the corresponding 4-aryl substituted 5-alkoxycarbonyl-6-methyl-3,4-dihydropyridones 4 in good yields. Quantum chemical calculations reveal a non-planar molecule with a distorted dihydropyridone ring and two favoured conformations. The 13C nmr data and theoretical calculations support a strong push-pull effect on the olefinic moiety. |
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