Studies on pyrazines. 31 Alkylation of chloropyrazine N-oxides by nickel-catalyzed cross-coupling reaction with dialkylzincs

3-Chloro-2,5-dimethylpyrazine 1-oxide underwent cross-coupling with dialkylzinc reagents forming 3-alkyl-2,5-dimethylpyrazine 1-oxides. The reaction was realized by catalytic 1,3-bis(diphenylphosphino)-propane nickel(II) chloride and the optimum results were examined.