Chemical silicon surface modification and bioreceptor attachment to develop competitive integrated photonic biosensors |
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Authors: | Jorge Escorihuela María José Ba?uls Javier García Castelló Veronica Toccafondo Jaime García-Rupérez Rosa Puchades ángel Maquieira |
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Affiliation: | 1. Centro de Reconocimiento Molecular y Desarrollo Tecnológico, Departamento de Química, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain 2. Nanophotonics Technology Center, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain
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Abstract: | Methodology for the functionalization of silicon-based materials employed for the development of photonic label-free nanobiosensors is reported. The studied functionalization based on organosilane chemistry allowed the direct attachment of biomolecules in a single step, maintaining their bioavailability. Using this immobilization approach in probe microarrays, successful specific detection of bacterial DNA is achieved, reaching hybridization sensitivities of 10?pM. The utility of the immobilization approach for the functionalization of label-free nanobiosensors based on photonic crystals and ring resonators was demonstrated using bovine serum albumin (BSA)/anti-BSA as a model system. |
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