Separation of phenothiazines in aqueous and non-aqueous capillary electrophoresis |
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| Authors: | Rongying Wang Xiaoning Lu Huijun Xin Mingjia Wu |
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| Affiliation: | (1) Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, National Analytical Research Center of Electrochemistry and Spectroscopy, 130022 Changchun, Julin, P.R. China |
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| Abstract: | Summary Four phenothiazines, promethazine, dioxypromethazine, chlorpromazine, and trifluoperazine have been separated by capillary electrophoresis using N,N,-dimethylformamide (DMF) as separation medium with UV absorbance detection. High voltage and concentrated buffer were used with small current and low electroosmosis. Good resolution and high column efficiency were obtained. Separation selectivity in DMF was different from that in water because of the different solvation interactions. The influence of buffer composition on separation selectivities and electroosmosis were also studied. |
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| Keywords: | Capillary electrophoresis Non-aqueous media Drug separation Phenothiazines |
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