| 甲磺酸卡莫他特的合成 |
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| 引用本文： | 尹秀梅,全红梅,朴宪,全哲山.甲磺酸卡莫他特的合成[J].化学研究与应用,2004,16(6):859-860. |
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| 作者姓名： | 尹秀梅 全红梅 朴宪 全哲山 |
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| 作者单位： | 延边大学药学院,吉林,延吉,133000;延边药检所,吉林,延吉,133000 |
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| 摘 要： | 甲磺酸卡莫他特是口服有效的丝氨酸蛋白酶抑制剂。文献的合成方法有二种。其中一种为化合物3先与SOCl2反应成酰氯后，再与化合物2反应。
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| 关 键 词： | 甲磺酸卡莫他特 胰腺炎 合成 |
| 文章编号： | 1004-1656(2004)06-0859-02 |
| 修稿时间： | 2004年3月2日 |
Synthesis of Camostat mesilate |
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| YIN Xiu-mei,QUAN Hong-mei,PIAO Xian,QUAN Zhe-shan.Synthesis of Camostat mesilate[J].Chemical Research and Application,2004,16(6):859-860. |
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| Authors: | YIN Xiu-mei QUAN Hong-mei PIAO Xian QUAN Zhe-shan |
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| Institution: | YIN Xiu-mei~1,QUAN Hong-mei~1,PIAO Xian~2,QUAN Zhe-shan~ |
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| Abstract: | Camostat mesilate was synthesized from 4-aminobenzoic acid by reaction with cyanamid to obtain 4-guanidinobenoic acid hydrochloride which reacted with 4-Hydroxyphenylacetyl dimethylaminoaceylmthylat was prepared from 4-hydroxyphenylacetic acid and N,N-dimethyl-2-chloride-acetamin.Compound structures were confirmed by MS,IR and ()~1H-NMR.The overall yield of the improved procedure was 56%. |
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| Keywords: | Camostat mesilate pancreatitis sythesis |
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