| 链脲佐菌素影响大鼠脂肪酸代谢的NMR研究 |
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| 引用本文： | 徐雯欣,安艳捧,唐惠儒.链脲佐菌素影响大鼠脂肪酸代谢的NMR研究[J].波谱学杂志,2013,30(2):204-212. |
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| 作者姓名： | 徐雯欣 安艳捧 唐惠儒 |
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| 作者单位： | 波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院武汉物理与数学研究所),湖北武汉430071;中国科学院大学,北京100049;波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院武汉物理与数学研究所),湖北武汉430071 |
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| 基金项目： | 国家重点基础研究发展计划("973"计划)资助项目，国家自然科学基金资助项目，中国科学院知识创新工程资助项目 |
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| 摘 要： | 脂代谢紊乱是心血管疾病等糖尿病并发症的公认危险因素，其早期检测是有效预防这些疾病的基础. 该文使用中等剂量链脲佐菌素(STZ)诱导的1型糖尿病大鼠模型，通过分析诱导后第5天和第12天的扩散加权1H NMR谱, 研究了血浆脂肪酸组成的动态变化规律. 结果表明，STZ作用早期主要特异性损伤胰岛β-细胞，使机体产生1型糖尿病表型. 伴随病程的发展，血浆总不饱和脂肪酸与单不饱和脂肪酸含量增高，而多不饱和脂肪酸与单不饱和脂肪酸的比值降低. 这些说明STZ对机体脂肪酸代谢有显著影响，且血浆不饱和脂肪酸含量很可能是比甘油三酯与脂蛋白等更为灵敏的糖尿病发生发展筛查指标.
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| 关 键 词： | 核磁共振(NMR) 糖尿病 脂肪酸 链脲佐菌素 |
| 收稿时间： | 2012-05-14 |
NMR Studies of Streptozotocin Effects on Rat Plasma Fatty Acids |
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| XU Wen-xin
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AN Yan-peng
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TANG Hui-ru.NMR Studies of Streptozotocin Effects on Rat Plasma Fatty Acids[J].Chinese Journal of Magnetic Resonance,2013,30(2):204-212. |
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| Authors: | XU Wen-xin AN Yan-peng TANG Hui-ru |
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| Institution: | 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;;
2. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Lipid metabolic dysfunction is a well-accepted risk factor of diabetic complications.Cardiovascular complications of diabetes are the leading cause of diabetic death. In this work, the dynamic changes in plasma levels of unsaturated fatty acids (UFAs) were measured, using diffusion-edited 1H NMR spectroscopy, in a rat model of streptozotocin (STZ)-induced type 1 diabetes. The results showed that STZ treatment induced elevated UFAs and monounsaturated fatty acids levels in the plasma, and the dynamic changes of fatty acid ratios correlated well with the progression of diabetes. It was proposed that plasma levels of UFAs might be more sensitive indicators for development of type 1 diabetes than clinical lipid screening indices, such as triglyceride (TG) and high-density lipoprotein (HDL) levels. |
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| Keywords: | NMR plasma fatty acid streptozotocin |
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