Efficient method for the synthesis of chiral pyrrolidine derivatives via ring-closing enyne metathesis reaction |
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Authors: | Yang Qian Alper Howard Xiao Wen-Jing |
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Affiliation: | Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada. |
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Abstract: | [reaction: see text] A series of new pyrrolidine derivatives were prepared directly in very good yields, from the substrates containing a basic or nucleophilic N atom via ring-closing enyne metathesis reaction under mild reaction conditions. Moreover, the reaction occurs smoothly without the presence of ethylene gas. |
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