Oxidation of benzylic methylenes to ketones with Oxone-KBr in aqueous acetonitrile under transition metal free conditions |
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| Authors: | Lixia YinJingjing Wu Juan XiaoSong Cao |
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| Affiliation: | Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | A green and highly efficient protocol for the oxidation of benzylic methylenes to their corresponding ketones with a combination of Oxone and KBr in aqueous acetonitrile is developed. The H218O labeling experiment demonstrated that the oxygen introduced into ketone originated from water. A plausible mechanism was also suggested. |
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| Keywords: | Oxidation Oxone Benzylic methylenes Labeling experiment |
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