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Synthesis of 1-aminopyrrolizidine alkaloid (−)-absouline by stereoselective aminoconjugate addition |
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| Authors: | Emily J. EklundRobert D. Pike Jonathan R. Scheerer |
| Affiliation: | Department of Chemistry, The College of William & Mary, PO Box 8795, Williamsburg, VA 23187, USA |
| Abstract: | The diastereoselective aminoconjugate addition of benzylamine and lithiobenzylamine to both E and Z-configured vinylogous proline derivatives has been investigated. The results from this study have enabled the stereoselective synthesis of the 1-aminopyrrolizidine alkaloid (−)-absouline. |
| Keywords: | (&minus )-Absouline Pyrrolizidine alkaloids Horner-Wadsworth-Emmons olefination Heteroconjugate addition Alkaloid synthesis |
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